A Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy

Near-infrared (NIR) activatable upconversion nanoparticles (UCNPs) enable wireless-based phototherapies by converting deep-tissue-penetrating NIR to visible light. UCNPs are therefore ideal as wireless transducers for photodynamic therapy (PDT) of deep-sited tumors. However, the retention of unsequestered UCNPs in tissue with minimal options for removal limits their clinical translation. To address this shortcoming, biocompatible UCNPs implants are developed to deliver upconversion photonic properties in a flexible, optical guide design. To enhance its translatability, the UCNPs implant is constructed with an FDA-approved poly(ethylene glycol) diacrylate (PEGDA) core clad with fluorinated ethylene propylene (FEP). The emission spectrum of the UCNPs implant can be tuned to overlap with the absorption spectra of the clinically relevant photosensitizer, 5-aminolevulinic acid (5-ALA). The UCNPs implant can wirelessly transmit upconverted visible light till 8 cm in length and in a bendable manner even when implanted underneath the skin or scalp. With this system, it is demonstrated that NIR-based chronic PDT is achievable in an untethered and noninvasive manner in a mouse xenograft glioblastoma multiforme (GBM) model. It is postulated that such encapsulated UCNPs implants represent a translational shift for wireless deep-tissue phototherapy by enabling sequestration of UCNPs without compromising wireless deep-tissue light delivery.     

锦屏一级水电站运行期谷幅变形特性与影响因素分析

通过对锦屏一级水电站运行期跨江段谷幅历年变形值进行比较分析,总结运行期谷幅的变形规律和左岸边坡的变形收敛情况;采用逐步回归分析方法,分析运行期边坡谷幅变形的影响因素,分析库岸岩体变形与库水位、气温及其他作用因子的相关性,总结运行期左岸变形的时空分布规律与特点;通过各种观测手段与谷幅变形进行对比分析,对谷幅观测的可靠性进行验证,论证谷幅成果的可靠性和真实性。     

施工现场标准化管理探讨

通过对神华宁煤400万t/a煤化工副产品深加工综合利用项目60万t/a聚丙烯装置施工作业现场的标准化研究,从技术团队的选择、计划进度控制、现场施工管理、文档资料规范等几个方面,探讨施工作业现场标准化作业的方法,为提高施工作业现场管理提供一些有益的建议。     

Multicarrier energy systems: Optimization model based on real data and application to a case study

Multicarrier energy systems are increasingly used for a number of applications, among which the supply of electricity, heating, and cooling in buildings. The possibility of switching between different energy sources is a crucial advantage for the optimal fulfillment of the energy demand. The flexibility of these systems can benefit from the integration with smart grids, which have strong variations in time during their operation. The energy price is the parameter that is usually considered, but also the primary energy factor and the greenhouse gases emissions need to be accounted. This paper presents an application of an operational optimization method for a multicarrier energy system, based on real data–driven model and applied to different countries. The generation plant of a hospital is considered as case study, coping with multiple energy needs by relying on different conversion technologies. The optimal operation of the system shows a wide range of variability, depending on the chosen objective function, the hour of the day, the season, and the country. The results are affected mostly by the energy mix of the electricity supplied from the power grid, which has a direct influence on the primary energy consumption and the greenhouse gases emissions and an indirect influence on the electricity prices.     

基于改进词嵌入表示和卷积神经网络的银行智能派单系统的研究

银行智能派单系统的实现和功能完善,对银行提升客户满意度、提高突发事件处理效率、降低人工处理成本等非常重要。针对现有的基于Word2vec和TextCNN模型的银行智能派单系统进行了改进,针对特征词权重表达性弱,特征词类别及位置区分性弱等问题,提出基于改进TF-IDF加权的Word2vec词嵌入表示和卷积神经网络结合的银行智能派单系统:首先利用Word2vec模型得到输入事件单的词嵌入向量;再针对经典TF-IDF方法不具备类别区分性、位置区分性,也没有考虑极端频率特征词代表性的情况,提出改进型TF-IDF算法,计算每个特征词的权重,得到基于改进TF-IDF加权的Word2vec词嵌入表示;最后在卷积神经网络模型中进行训练,通过迭代训练最终得到分类器,利用分类器可对输入事件单信息自动进行系统类别的判断。实验结果表明改进词嵌入表示的银行智能派单系统分类模型的宏查准率、宏查全率、准确率以及宏F1值都得到进一步的提高。     

旋转叶片电加热防冰系统设计与应用

在开展结冰试验时，结冰风洞风扇叶片前缘有结冰风险，影响风洞安全运行。针对大型旋转叶片结冰问题，提出了旋转叶片电加热防冰系统设计方法，研制了大型结冰风洞旋转叶片电加热防冰系统。首先，研制了内置电加热单元和温度反馈的防冰叶片。针对叶片复杂的工作环境，提出一种新的旋转叶片电加热防冰功率计算方法，通过精确测量和方案优化，设计了基于特殊环境的分半式、大尺寸、高线速度、碳刷自动移开/压紧的导电滑环。最后，采用变结构分级温度闭环和试验参数连锁防冰控制策略解决了旋转叶片结冰问题。该系统已应用于大型结冰风洞，运行中加热电流和叶片温度反馈信号传输连续，所有旋转叶片前缘快速加热且温度分布均匀，防冰效果好。     

氯碱企业快速熔断器运行状况调查报告

以2018年58家氯碱企业供电、整流技术与设备现状调查数据为依据,阐述了国内氯碱企业中快速熔断器的运行状况。调查数据中包括50家氯碱企业的快速熔断器的基本运行数据、投运时间及设备来源等。汇总了各企业在氯碱生产中使用快速熔断器时遇到的问题、发生的故障甚至酿成的生产事故及对氯碱生产造成的影响。并分析了事故发生的原因,提出了预防及解决措施,总结了事故处理经验,旨为氯碱生产提供参考依据。     

改进BP神经网络的再生粗骨料混凝土强度预测*

抗压强度作为评价再生混凝土主要性能指标之一,从四篇文献中搜集了43个抗压强度样本。基于改进的BP神经网络理论,建立了以再生粗骨料取代率、水灰比、龄期为输入,抗压强度为输出的神经网络模型,其结构形式为3-7-9-1。对该网络进行训练和学习,对并测试样本进行检测,结果表明,训练效率不仅大大提高,且而误差较小,并结合回归拟合系数,进一步表明该模型能够有效的的预测再生混凝土抗压强度值,能满足工程需要。     

某污水处理厂MBR膜系统改造与运行管理

某污水处理厂设计规模为10万t/d,采用AAO+MBR工艺,设计出水水质满足《城镇污水处理厂污染物排放标准》(GB 18918-2002)一级A标准。由于运行时间较长,MBR运行系统存在产能下降、膜丝断丝脱落、污堵和清洗频次以及强度增加等问题,严重影响正常生产运行。针对MBR系统运行中存在的问题,文中提出具体改造建议,并总结运行经验,进一步优化MBR膜系统的运行维护管理,为其他污水厂MBR膜系统运行问题提供解决思路和维护管理经验。